Totally Derma Review UK 2026: Is This £105 Collagen Drink Worth It?

What Is Totally Derma?

Totally Derma is a powdered nutraceutical collagen drink supplement that positions itself well above the mainstream collagen category. It was originally developed for osteoarthritis patients using Arthred, a patented pharmaceutical-grade bovine collagen peptide, before its skin, hair, nail, and menopause benefits expanded the product’s audience into the aesthetics and anti-ageing market.

The product is widely recommended by UK dermatologists and aesthetic clinics, and it is commonly sold through skin clinics rather than high-street retailers. That distribution channel tells you something about the positioning: this is a clinical-grade supplement sold through professional channels, not a beauty-counter impulse buy. Nature’s Fix is one of the few online retailers stocking it outside of clinic environments, which makes it more accessible for buyers who want the product without a clinic consultation.

The formulation goes well beyond a simple collagen peptide powder. Totally Derma combines 10,000mg of patented Arthred bovine collagen with 210mg of patented Synovoderma hyaluronic acid and seven antioxidant and mineral co-factors. Each ingredient is present at what the brand describes as therapeutic dosage, and the formulation is designed to support collagen synthesis, maintenance, and repair from the inside out.

The Formulation: What Makes It Different

This is where Totally Derma genuinely separates itself from the mainstream UK collagen market. The formulation uses two patented hero ingredients and a supporting cast of co-factors, each with a specific role in the collagen synthesis pathway.

Arthred Bovine Collagen Peptides (10,000mg)

Arthred is a patented hydrolysed bovine collagen sourced via Gelita AG, the world’s largest collagen peptide manufacturer. The peptides are enzymatically processed to a uniform 3kDa (3,000 Dalton) molecular weight, which is significantly smaller than most collagen supplements on the market. For context, a typical collagen powder sits around 5,000 Daltons, and a standard sports protein drink around 70,000 Daltons. The smaller molecular size allows for a claimed 95% absorption rate, which is backed by clinical serum hydroxyproline data showing elevated blood levels post-consumption.

The collagen delivers Types I, II, and III, covering skin (Type I), cartilage and joints (Type II), and connective tissue broadly (Type III). This multi-type coverage from a single bovine source is genuinely different from the “multi-collagen” blends that dilute each type across multiple sources. Arthred delivers all three types from one enzymatically controlled source at a clinically relevant total dose.

Synovoderma Hyaluronic Acid (210mg)

This is, in our view, one of the strongest differentiators. Most collagen supplements either exclude hyaluronic acid entirely or include it at modest doses (Elavate’s 120mg, for example). Totally Derma uses Synovoderma, a patented HA formula processed to reduce the molecular weight to 50,000-200,000 Daltons for enhanced absorption through the digestive tract. At 210mg, this is a genuinely therapeutic dose, not a label ingredient.

Collagen and hyaluronic acid work in a positive feedback loop: the more collagen you produce, the more HA your body generates, and the more HA present, the more it stimulates fibroblast proliferation within the collagen matrix. A supplement that delivers both at therapeutic doses is, in our assessment, doing meaningfully more than one that delivers collagen alone.

The Antioxidant and Mineral Co-Factors

The supporting ingredients each serve a specific function in the collagen synthesis and protection pathway:

Vitamin C: Essential cofactor for collagen synthesis. Without adequate vitamin C, your body cannot effectively convert collagen peptides into new collagen.

Grape Seed Extract (95% proanthocyanidins): Powerful antioxidant that bonds to collagen, negates free radicals, and supports collagen development and skin cell renewal.

Green Tea Extract (EGCG): Anti-inflammatory antioxidant that protects existing collagen from UV and oxidative damage.

Alpha Lipoic Acid: Both water-soluble and fat-soluble antioxidant, which means it protects collagen in more tissue types than single-solubility antioxidants.

Zinc: Essential mineral for cell division and collagen synthesis. Deficiency directly impairs wound healing and skin repair.

Manganese: Cofactor for enzymes involved in collagen formation.

Copper: No other mineral can replace copper’s role in stimulating collagen production. Most enzymes responsible for collagen synthesis depend on it as a cofactor.

Who Is Totally Derma For?

Totally Derma is not for everyone, and the price ensures that. At £3.50/day it is the most expensive collagen supplement we cover on this site. But for certain buyers, the formulation justifies the premium:

Women in perimenopause or menopause. A self-reporting study using Totally Derma found that 90% of participants experienced relief across the full range of GSM (Genitourinary Syndrome of Menopause) symptoms. The combination of collagen, HA, and anti-inflammatory antioxidants addresses skin thinning, vaginal dryness, joint stiffness, and the broader connective tissue changes driven by oestrogen decline. See our best collagen for menopause guide for the full category comparison.

People with joint pain or osteoarthritis. Totally Derma was originally formulated for this use case. Arthred has its roots in medical heritage with osteoarthritis, and the Type II collagen content directly targets cartilage support. If you currently supplement with glucosamine, chondroitin, or MSM for joint health, Totally Derma is, in our view, a more comprehensive alternative.

Buyers who want a clinic-grade product at home. If you are already spending money on aesthetic treatments (microneedling, Profhilo, chemical peels, laser resurfacing) and want an internal supplement to complement and prolong those results, Totally Derma is widely recommended by the clinics performing those treatments.

People who have tried cheaper collagen and want to step up. If you have been using a standard collagen peptide powder (Ancient + Brave, Planet Paleo, etc.) for 3-6 months and feel you have plateaued, the patented ingredients and co-factor approach in Totally Derma represents a genuine upgrade rather than just a more expensive version of the same thing.

Pricing: Is £105/Month Justified?

This is the question, and we will answer it honestly.

At £105 for a 30-day supply (£3.50/day), Totally Derma costs roughly 2-5x more than the other bovine collagen supplements we cover:

The premium is real and significant. But what you are paying for is also real and significant: two patented ingredients with their own absorption and clinical data (Arthred and Synovoderma), seven co-factors at therapeutic doses, and a formulation designed by pharmaceutical scientists rather than a wellness marketing team.

Our honest assessment: if you can comfortably afford £105/month and you want the most comprehensively formulated collagen supplement available in the UK, Totally Derma is, in our view, the strongest option. If £105/month is a stretch, you will get meaningful results from Absolute Collagen or Ancient + Brave at a fraction of the cost. Collagen supplementation at any clinically relevant dose is better than no supplementation, and the diminishing returns between a £40/month product and a £105/month product are real.

How to Take Totally Derma

Serving size: One level scoop (12g) mixed with 250ml of water, juice, a smoothie, or yoghurt. Vanilla flavour, sugar-free (sweetened with xylitol).

Best time: Before bed is the brand’s recommendation. The majority of collagen synthesis takes place in the first couple of hours of sleep, so evening dosing aligns supplement availability with the body’s natural production window. If evening does not suit your routine, morning on an empty stomach or after food works too.

Coffee separation: Do not take Totally Derma within 90 minutes of having coffee. The tannins and polyphenols in coffee can interfere with absorption. Keep a 2-hour gap.

Minimum commitment: The brand recommends a minimum of 90 days for best results. Most users report hydration improvements at around 3 weeks and visible skin changes from 8 weeks.

When to Expect Results

3 weeks: Improved skin hydration. This is typically the first noticeable change and is consistent with the HA component increasing water retention in the dermis.

6 weeks: Longer, stronger hair and nails. The 12-week clinical trial reported this improvement at the 6-week mark.

8 weeks: Visible reduction in fine lines and wrinkles. Physical signs of collagen rebuilding become apparent in the skin’s surface texture.

12 weeks+: Joint flexibility improvements and broader systemic benefits (gut health, menopausal symptom relief). One trial participant reported new hair growth in an area of previous hormonal hair loss one month after the trial ended.

How Totally Derma Compares to Other UK Collagen Brands

vs Ancient + Brave True Collagen

Completely different products at completely different price points. True Collagen is a pure, single-ingredient bovine collagen peptide powder at 5,000mg per serving and ~£0.72/day on subscription. Totally Derma is a multi-ingredient nutraceutical with patented collagen and HA at 10,000mg per serving and £3.50/day. True Collagen is the sensible starting point for most buyers. Totally Derma is the upgrade for people who want a more comprehensive formulation and can afford the premium. See our Ancient + Brave review.

vs Absolute Collagen

Different collagen type (bovine vs marine), different format (powder vs liquid sachet), vastly different price point (£3.50/day vs ~£1.43/day). Absolute Collagen has its own clinical trial (130-person study), wider retail availability, and a seven-product range. Totally Derma has patented ingredients, therapeutic-dose HA, and clinic-grade positioning. For most buyers, Absolute Collagen is the better value proposition. For buyers who specifically want a bovine collagen with comprehensive co-factors, Totally Derma offers something Absolute Collagen does not. See our Absolute Collagen review.

vs Planet Paleo Pure Collagen

Both are bovine collagen powders, but Totally Derma is a fully formulated nutraceutical while Planet Paleo is a pure single-ingredient peptide. Planet Paleo at £40.99 for a 450g pouch delivers roughly a month of daily use at a fraction of Totally Derma’s cost. Totally Derma’s advantage is the patented ingredients, HA, and antioxidant co-factors. Planet Paleo’s advantage is significantly lower cost and the MSC-certified marine option. See our Planet Paleo review.

Pros and Cons

Our Verdict on Totally Derma

Clinic-Grade Collagen

Totally Derma Nutraceutical Collagen Skin Drink

£105.00 (360g, 30 servings)

• 10,000mg patented Arthred bovine collagen (Types I, II, III)
• 210mg patented Synovoderma hyaluronic acid
• Vitamin C, grape seed extract, green tea extract, alpha lipoic acid
• Zinc, manganese, copper for collagen synthesis
• 3kDa molecular weight, 95% absorption claimed
• Vanilla flavour, sugar-free, allergen-free
• Stocked at Nature’s Fix with domestic UK delivery

Buy at NaturesFix (£105) →

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